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KMID : 0381919990290030331
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Korean Journal of Microscopy
1999 Volume.29 No. 3 p.331 ~ p.341
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A Study on the Morphology of Dysmorphic Erythrocytes for the Differential Diagnosis in Hematuria
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Yoon Chul-Jong
Park Chung-Oh
Moon Hee-Joo
Yoon Ki-Eun
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Abstract
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Examination of the morphology of red blood cells in the urine has been shown to be a promising adjunct in determining whether hematuria represents glomerular or nonglomerular bleeding. This is due to distortion of RBCs as they Pass across the basement membrane of the glomerular capillaries. It is concluded that is method can greatly help the clinician in distinguishing between glomerular and nonglomerular bleeding in patients with hematuria and channeling such patients toward the most appropriate investigations. We have experimented dysmorphic red blood cells that 5 patients of the hematuria are distorted with irregular outlines and often have small blobs extruding from the red cell membrane. Tried urinary sediments were seen with phase contrast microscope and confirmed scanning electron microscope. There are seen acanthocytes, anulocytes, ghost cells and sphero-echinocytes in dysmorphic erythrocytes. Clinical diagnosis was referred from the result of the biopsy-proven. Scanning electron microscopic findings of the hematuria are good diagnostic tool that disclose in distorted red blood cells from patients with glomerular disorders.
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KEYWORD
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Hematuria, Glomerular disease, Electron microscopy, Dysmorphic erythrocytes
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